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22 Night Complete Mississippi River Experience and Land Tour

From New Orleans to St Paul
  • American Serenade
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American Serenade

American Cruise Lines
4 Stars
  • Cruise #: 14240955
  • Departs: Fri, Jun 11, 2027
  • Returns: Sat, Jul 3, 2027
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    Itinerary Summary

    Day by Day Details

    Land Segment of Itinerary

    Friday - Jun 11, 2027
    Day
    1
    New Orleans, United States
    • New Orleans, United States
    New Orleans is a city alive with music, culture, and history at every turn. Explore its vibrant streets, savor iconic cuisine, and soak up the energy of this unforgettable location. A walk through the French Quarter reveals iron balconies, Creole townhouses, and architectural details that reflect the city's French and Spanish heritage. The New Orleans jazz legacy thrives, from street musicians to the traditional performances at Preservation Hall, while local restaurants showcase the bold flavors of Creole cuisine. Along the nearby riverfront, the Mississippi's role in steamboat commerce and trade comes into focus, making this vibrant port the perfect starting point for a journey on the river. ...
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    Land Segment of Itinerary

    Saturday - Jun 12, 2027
    Day
    2
    New Orleans, United States
    • New Orleans, United States

    Cruise Segment of Itinerary

    Day 2 - Saturday - Jun 12, 2027
    Day
    2
    Cruise Begins
    • Cruise Begins
    • New Orleans, United States
    • Cruising the Mississippi River, United States
    Board your ship and wave goodbye to New Orleans as your Mississippi River cruise begins. Traveling north, the scenery shifts from the city's iconic waterfront to the working river corridor. Levees line the banks, cargo vessels move through the channel, and bustling port facilities showcase the river's vital role in American trade and transportation. ...
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    Sunday - Jun 13, 2027
    Day
    3
    Oak Alley, United States
    • Oak Alley, United States
    This stop along the Great River Road highlights the landscapes and stories of the lower Mississippi. Visit Oak Alley, a 19th-century Greek Revival mansion built during the region's sugar boom and known for its avenue of live oaks. Explore the grounds, wander beneath the oaks, and see how the property evolved from a working farm into a preserved historic site. Step inside the interiors and learn about its role in the sugar industry. You can also join a Cajun cooking experience, prepare jambalaya while hearing traditional folktales, and learn how these recipes have been passed down through generations. Another option is a narrated boat ride through nearby wetlands, where cypress and tupelo trees draped in Spanish moss frame the waterways. From a covered boat, look for wildlife such as alligators, nutria, turtles, and wading birds in this part of the Mississippi River Delta ecosystem. ...
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    Monday - Jun 14, 2027
    Day
    4
    Baton Rouge, United States
    • Baton Rouge, United States
    Welcome to Baton Rouge, the capital of Louisiana, whose name comes from a "red stick" that once marked a boundary used by the Native Americans. The city echoes with the stories of its most notable figures, particularly the bold Governor and Senator Huey P. Long. His political and architectural legacy is reflected in landmarks such as the Old State Capitol Museum, housed in a majestic Gothic-style castle from 1852, and the current 34-story State Capitol, a striking example of Depression-era Art Deco architecture built from Louisiana limestone and adorned with marble. Discover Capitol Park Museum, where Louisiana's vibrant culture comes to life, from the sounds of Louis Armstrong to the pageantry of Mardi Gras traditions. Walk in history's footsteps on a guided exploration of key Civil War sites tied to the Battle of Baton Rouge. Visit Magnolia Cemetery and stand on the very ground where some of the conflict's most intense moments unfolded. Follow downtown along the Baton Rouge Riverfront, where modern art, river views, and old architecture blend seamlessly. Browse local shops and experience the dynamic energy of a city shaped by a rich and complex past. ...
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    Tuesday - Jun 15, 2027
    Day
    5
    St Francisville, United States
    • St Francisville, United States
    Perched high above the river, St. Francisville invites you to step into a world of small-town charm infused with Southern Gothic intrigue. Set on bluffs protected from flooding, this scenic destination connects the lower Mississippi's estates with the Delta's natural landscapes. Visit The Myrtles, an 18th-century estate where history and mystery intertwine. Stroll through the beautifully preserved grounds of Rosedown, known for its expansive gardens and refined architecture. Explore the Audubon State Historic Site to discover the region's artistic and natural legacy, then venture to the Port Hudson Historic Site, where pivotal Civil War events unfolded. Wander the district, where Royal Street, century-old churches, and preserved community buildings showcase the town's character. ...
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    Wednesday - Jun 16, 2027
    Day
    6
    Natchez, United States
    • Natchez, United States
    In the heart of Natchez, where the Mississippi River bends, grand homes stand as a testament to the city's wealth as a major river port. After the French built a fort here in 1716 near communities of the Natchez people, the settlement grew into one of the most prosperous towns along the river. Largely preserved despite early Union occupation during the Civil War, Natchez remains home to one of Mississippi's most intact collections of iconic residences. Discover the stunning Rosalie Mansion, known as "Our Lady on the Bluff". Led by a guide, explore this beautiful home overlooking the river, with elegant interiors and period furnishings that offer a glimpse into Natchez's past. Then relax and experience the town the old-fashioned way, by horse-drawn carriage, while listening to tales of the city's rise as one of America's wealthiest before the Civil War. ...
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    Thursday - Jun 17, 2027
    Day
    7
    Vicksburg, United States
    • Vicksburg, United States
    Overlooking the river, Vicksburg is best known for its pivotal role in the Civil War and its commanding views of the waterway that shaped its past. Visit Vicksburg National Military Park, where preserved battlefields, monuments, and the restored ironclad USS Cairo tell the story of the decisive campaign that helped turn the tide of the war. On a guided excursion, explore Vicksburg's oldest neighborhood, where you can admire the Duff Green Mansion, once a hospital during the 47-day siege, and Tully's Cave, which reveals how residents survived the bombardment. Finally, walk through downtown to discover historic architecture, riverfront murals, museums, and local shops that reflect the city's connection to the Mississippi River. ...
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    Friday - Jun 18, 2027
    Day
    8
    • Greenville, United States
    Dubbed the heart and soul of the Mississippi Delta, Greenville invites you into a landscape and culture shaped by fertile farmland, river life, and the enduring legacy of the blues. Set along the shores of Lake Ferguson and surrounded by levee-protected fields, this storied town reflects the agricultural backbone of the region, where cotton once ruled and a distinct cultural identity took root. Experience the origins of blues at the B.B. King Museum and Delta Interpretive Center, where the life of B.B. King is shared alongside the broader tale of Mississippi's musical heritage. Through immersive exhibits and vivid storytelling, uncover how this iconic music emerged. ...
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    Saturday - Jun 19, 2027
    Day
    9
    • Tunica, United States
    • Bus Travel
    • Tunica, Mississippi
    • Bus Travel
    • Tunica, United States
    Discover Tunica, a charming Delta river town where the Mississippi and its levees shape the landscape and daily life. Stop by the riverfront for sweeping views of the water and surrounding farmland, and experience firsthand how this mighty river has influenced the culture, past, and rhythm of the Delta. Among Tunica's must-see attractions is the Gateway to the Blues Museum, where exhibits display the rich musical traditions of the Mississippi Delta and the artists who defined the blues. Nearby, Tunica river park offers another perspective on the region, with museum displays highlighting the geology, wildlife, and cultural history of the lower Mississippi. Set along a scenic riverwalk, the museum overlooks the water, where visitors can see views from the ship's dock. ...
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    Sunday - Jun 20, 2027
    Day
    10
    Memphis, United States
    • Memphis, United States
    Welcome to Tennessee and the vibrant city of Memphis, a cultural landmark along the Mississippi where musical legacy and civil rights are deeply connected to the river. Walk along Beale Street, home to legendary blues clubs and live venues that carry forward the sounds that shaped the city. Step inside Sun Studio, the birthplace of rock 'n' roll, and see where music legends recorded their groundbreaking hits. Then, visit the National Civil Rights Museum at the Lorraine Motel for a powerful, immersive look into the American Civil Rights Movement. Celebrate the life of the King of Rock 'n' Roll at Graceland, viewing the iconic home, exploring personal artifacts, and tracing the life and influence of Elvis Presley. Take a guided motorcoach exploration through downtown Memphis landmarks before returning to the revitalized riverfront. ...
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    Monday - Jun 21, 2027
    Day
    11
    • River Cruising
    Cruising from Memphis to Cape Girardeau offers a memorable journey along the river's scenic shores. As the ship travels north, the river gradually narrows, flat farmland stretches along the banks, and the channel curves through tree-lined shores, creating an ever-changing landscape. Onboard, enjoy expansive river views from the sun deck, lounge, or your private balcony, and take in lively performances or connect with fellow guests, making every moment both relaxing and enriching. ...
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    Tuesday - Jun 22, 2027
    Day
    12
    • Cape Girardeau, United States
    Cape Girardeau is a quaint Midwestern river community with a walkable downtown. Its waterway is known for large floodwall murals that illustrate the area's history and connection to river trade. From the shoreline, visitors can also see the Bill Emerson Memorial Bridge spanning the river-a modern landmark that frames views of the upper Mississippi and marks the ship's entry into this region. Several attractions lie just steps from the dock, making them ideal for local exploration. Wander through the Cape Girardeau Heritage Museum, housed in a former fire station, where exhibits showcase the city's growth. Step inside the Red House Interpretive Center, where the story of early founder Louis Lorimier and the notable visit of Lewis and Clark come to life. Discover Old St. Vincent's Church and Glenn House to gain insight into daily life in earlier periods, from early settlers to riverfront communities. Stroll through the downtown district to experience the city's architecture, shops, and local charm. ...
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    Wednesday - Jun 23, 2027
    Day
    13
    • Cruising the Mississippi River, United States
    Relax as your journey continues along the Mississippi River. Here, locks and dams begin to appear, offering a close look at the system that manages water levels and allows vessels to navigate this section of the river. The shoreline begins to change as wooded hillsides and quieter riverbanks replace the industrial scenery seen farther south. Take in views from the sun deck, the lounge, or your private balcony while enjoying onboard programming that explores the history and navigation of the river. ...
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    Thursday - Jun 24, 2027
    Day
    14
    St Louis, United States
    • St Louis, United States
    Approaching the banks of St. Louis, Missouri, the skyline and the Gateway Arch rise along the river, marking one of the major Midwestern cities where the Mississippi and Missouri rivers meet. Located within Gateway Arch National Park, the Arch stands as a symbol of the nation's westward expansion and remains one of the most recognized St. Louis attractions. Enjoy a guided, narrated journey through downtown St. Louis, taking in the riverfront, City Garden, Soulard, Lafayette Square, and Forest Park. Experience the iconic Gateway Arch, explore the pre-boarding exhibits, and ascend 630 feet for breathtaking panoramic views. Then, visit the renowned Anheuser-Busch (Budweiser) facility to see the legendary Clydesdales' stables, the Brewhouse, and the Beechwood Aging Cellars, where signature beers are crafted to perfection. ...
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    Friday - Jun 25, 2027
    Day
    15
    • Cruising the Mississippi River, United States
    As you travel the Mississippi River toward Hannibal, taller, more dramatic bluffs and wooded shorelines rise along the banks. From the sun deck, you may also notice small towns and agricultural stretches that reflect the working landscape of this region. This portion of the journey offers a slower pace of scenic cruising, giving guests time to relax in one of the lounges, enjoy the coast from a private balcony, or take part in onboard enrichment activities that highlight the culture and history of the river. Don't miss cocktail hour, a chance to share stories with fellow travelers, before sitting down to a dinner inspired by local flavors. ...
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    Saturday - Jun 26, 2027
    Day
    16
    • Hannibal, United States
    Step into the world of Mark Twain in this idyllic river town, where the author's stories of Tom Sawyer and Huckleberry Finn come to life. Visit the Mark Twain Boyhood Home & Museum to experience life in the 1840s and the events that shaped his legendary writing. Stroll the preserved 19th-century streets and join a guided walk with a local interpreter, who brings the town's story to life through Mark Twain's own words. Visit Rockcliffe Mansion for stunning views of the river, and explore Mark Twain Cave, one of the region's most famous natural attractions, for an unforgettable underground adventure. ...
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    Sunday - Jun 27, 2027
    Day
    17
    • Cruising the Mississippi River, United States
    Settle into one of the spacious lounges aboard the riverboat as we continue cruising from Hannibal to Muscatine. On this stretch of scenic river cruising, the channel becomes narrower and we pass through additional locks while hillsides and dense forests rise along the shoreline. From the sun deck or your private balcony, relax and take in the view as we cruise through quieter stretches of the Mississippi River, with occasional sightings of regional wildlife. ...
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    Monday - Jun 28, 2027
    Day
    18
    • Muscatine, United States
    Along the upper Mississippi River in Iowa, Muscatine is a quiet river town with a relaxed pace and easy riverfront access, a noticeable change from the busier lower river cities. Walk along the riverfront where hillside views and tree-lined shores create a serene backdrop for exploration. Step inside the National Pearl Button Museum to explore Muscatine's distinctive legacy as the "Pearl Button Capital of the World". Uncover the fascinating process of crafting buttons from freshwater mussels and see how this once-booming industry shaped the city's economy and riverfront identity. Then, venture to Pine Creek Grist Mill, a beautifully restored 19th-century landmark nestled within Wildcat Den State Park. As one of the oldest and most well-preserved gristmills between the Mississippi River and the Rockies, it offers a vivid glimpse into the region's early milling heritage and rural craftsmanship. ...
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    Tuesday - Jun 29, 2027
    Day
    19
    • Dubuque, United States
    Dubuque, Iowa, overlooks the Mississippi River and blends historic architecture with walkable streets. Stroll the revitalized riverwalk and wander the city's quaint avenues, where preserved buildings bring Dubuque's past to life. Ride the Fenelon Place Elevator for a unique view of the steep terrain. Immerse yourself in the National Mississippi River Museum & Aquarium with hands-on exhibits, live wildlife displays, and interactive lessons on river navigation. Travel to the iconic Field of Dreams Movie Site to experience cinematic history, or observe local wildlife and plant life along the scenic waterway. ...
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    Wednesday - Jun 30, 2027
    Day
    20
    • Cruising the Mississippi River, United States
    As you sail from Dubuque to Winona, notice the shift into the Driftless Area, a unique geographic region where the river narrows and steep, wooded hills rise along the shoreline. The passage includes more locks and dams, making elevation changes along the Mississippi more visible and adding interest to the journey. Quiet stretches of river allow for wildlife sightings and a sense of calm, with fewer industrial areas than on the lower river. This segment is one of the most scenic of the itinerary, offering a chance to appreciate the natural beauty and subtle changes of the landscape. ...
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    Thursday - Jul 1, 2027
    Day
    21
    • Winona, United States
    Framed by towering bluffs and striking limestone cliffs, Winona is a picturesque river town where a charming downtown and scenic riverfront paths invite easy, unhurried exploration. Explore the Winona County History Center to see exhibits that highlight the area's cultural heritage and community life over the decades. Drive to Garvin Heights Lookout for breathtaking views that reveal the convergence of the Mississippi River, towns, and surrounding farmland. Visit the Minnesota Marine Art Museum, home to a remarkable collection of European and American marine and fine art. Take a narrated boat exploration to learn about the interesting past of Winona and its relation to the river. Bring your camera and binoculars to observe local wildlife like eagles, deer, and turtles. ...
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    Friday - Jul 2, 2027
    Day
    22
    • Red Wing, United States
    Overlooking the northern riverbanks, Red Wing has inspired artisans for over 150 years, its striking cliffs and sweeping river views fueling generations of artistic creativity. Visit the Red Wing Pottery Museum to admire beautifully preserved stoneware and regional folk art that reflect the town's rich craftsmanship. Take in a performance at the Sheldon Theatre, one of Minnesota's oldest venues, known for hosting national tours, international artists, and local productions. At the National Eagle Center, get an up-close look at bald eagles in an immersive setting. Finally, stop by the Red Wing Shoe Company flagship store to see the world's largest boot; standing over 20 feet tall, it's a true local icon. ...
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    Saturday - Jul 3, 2027
    Day
    23
    St Paul, United States
    • St Paul, United States
    Disembark in this dynamic capital city with convenient access to the Minneapolis/St. Paul airport or extend your stay to explore the region more fully. Discover Summit Avenue highlights, including Landmark Center and the historic Rice Park. Stop by the Mississippi River Visitor Center and nearby riverfront parks to trace the upper course of the Mississippi, then continue to Mounds Park for views of the river valley and downtown skyline. ...
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