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15 Night Grand Ohio River

From Pittsburgh to St Louis
  • American Melody
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American Melody

American Cruise Lines
4 Stars
  • Cruise #: 13933766
  • Departs: Sat, Jul 4, 2026
  • Returns: Sun, Jul 19, 2026
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    Suite
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    *Prices are per person based on double occupancy
    Includes taxes & fees
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    Itinerary Summary

    Day by Day Details

    Cruise Segment of Itinerary

    Saturday - Jul 4, 2026
    Day
    1
    Pittsburgh, United States
    • Pittsburgh, United States
    Long known for steel manufacturing, Pittsburgh was an essential stop along the Ohio River for national and international commerce, making it a wealthy town in the 18th and 19th centuries. Settle into your hotel and explore the city at your leisure. Learn about famous Americans such as Heinz, Carnegie, and others who called this vibrant city home. ...
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    Sunday - Jul 5, 2026
    Day
    2
    Pittsburgh, United States
    • Pittsburgh, United States
    Our ship docks near the famous point where the Allegheny and Monongahela Rivers join to begin the majestic Ohio River. As you cruise, delight in picturesque and ever-changing scenery, as early explorers did centuries ago.
    Monday - Jul 6, 2026
    Day
    3
    • Moundsville, West Virginia
    Located along the banks of the Ohio River, Moundsville offers a rich history. Deriving its name from the many Adena Indian burial mounds constructed here more than 2,000 years ago, the town is home to the largest conical burial mound in North America. Moundsville is a land of sacred past and promising future, accented with quaint neighborhoods and beautiful landscapes. ...
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    Tuesday - Jul 7, 2026
    Day
    4
    • Marietta, United States
    This picturesque, charming town rests at the confluence of the Muskingum River and the Ohio River and has five National Register Historic Districts with buildings that date back to the town's founding in 1788. Explore the first settlement in the Northwest Territory on the north side of the Ohio River. Hear stories of the compelling events that unfolded here which were spotlighted in the recent book entitled The Pioneers by Pulitzer Prize-winning historian David McCullough. ...
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    Wednesday - Jul 8, 2026
    Day
    5
    • Maysville, United States
    From the ship's landing, gaze upon the quaint town of Maysville, nestled into the hillside. After floating down the Mississippi River to sell their commodities in New Orleans, early flatboat travelers returned along the Natchez Trace Parkway to rejoin the Ohio River in this idyllic town, steeped in American history. Learn the importance of this location to the Underground Railroad efforts to smuggle runaway slaves across the river, as well as the influence that Harriet Beecher Stowe's visit to Maysville had on her novel, Uncle Tom's Cabin. Hear stories of area explorers, such as Simon Kenton, and hometown singer and movie star Rosemary Clooney. ...
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    Thursday - Jul 9, 2026
    Day
    6
    Cincinnati, United States
    • Cincinnati, United States
    The dramatic bridges that span the Ohio River provide an impressive scenic welcome to your visit to Cincinnati. As an early shipbuilding and shipping metropolis, the town became known as the "Queen City". Your adventures ashore reveal the highlights of this vibrant cultural center which include major sports franchises, a delightful zoo, and a botanical garden, as well as numerous theaters and museums, including the National Underground Railroad Freedom Center, a Smithsonian Affiliate Museum. Admire the eclectic architecture as you stroll along its charming streets and enjoy the diverse attractions, ranging from the abundant gardens of the Krohn Conservatory to the architectural wonders of St. Mary's Cathedral Basilica. Get a taste for local cuisine by trying Cincinnati Skyline Chili or stopping for a scoop at Graeter's ice cream shop, founded in 1870. ...
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    Friday - Jul 10, 2026
    Day
    7
    Cincinnati, United States
    • Cincinnati, United States
    Spend a second day in this mesmerizing city. Explore the Cincinnati Museum Center, which encompasses history, science, and children's museums in the art deco Union Terminal. View picturesque Eden Park, home of the Cincinnati Art Museum, Playhouse in the Park, and Krohn Conservatory.
    Saturday - Jul 11, 2026
    Day
    8
    Louisville, United States
    • Louisville, United States
    An impressive waterfront town arching up the hillside, Louisville has a long history of commerce and revelry. The town grew at a portage around the treacherous Falls of the Ohio, now inundated behind the Ohio River's Markland Dam. The historic importance of river commerce to the town is represented by the "Belle of Louisville" day excursion boat just down the banks, still operating after more than a century. Explore the impressive Churchill Downs to learn about the city's renowned Kentucky Derby, the oldest continuously held horse race in the country. Or stop by the Louisville Slugger Museum & Factory to see how the famous baseball bats are made. A visit to the Jim Beam American Outpost will lift your spirits as you savor samples and learn about the history of Kentucky bourbons. ...
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    Sunday - Jul 12, 2026
    Day
    9
    Louisville, United States
    • Louisville, United States
    Louisville has so much to offer so you will be excited for another day to continue your exploration. Admire the architecture of the city's adjacent and vibrant downtown or venture into the Old Louisville Historic Preservation District and stroll through the heart of the largest adjoining collection of Victorian mansions in the United States. ...
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    Monday - Jul 13, 2026
    Day
    10
    • Henderson, United States
    Henderson is a laid-back river town steeped in fascinating lore. Delight in a snapshot of small-town life here as children often gleefully splash in the waterfront fountains. While living here for almost two decades in the early 1800s, naturalist and artist John James Audubon created many of his extraordinary Birds of America masterpieces. Several of his paintings are recreated as bronze statues throughout the town and a visit to the National Register of Historic Places-listed John James Audubon Museum provides interesting insights into one of America's premier pioneer artists. Delve into WWII history at nearby Evansville's operational USS LST-325 (Landing Ship, Tank) amphibious vessel. ...
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    Tuesday - Jul 14, 2026
    Day
    11
    Evansville, United States
    • Evansville, United States
    Discover this delightful riverside city that is the perfect blend of modern and historic architecture. Evansville is home to Bally's Evansville, the state's first casino, as well as Mesker Park Zoo and Botanic Garden, one of the state's oldest and largest zoos. Explore the many local museums and take time for shopping and strolling along the charming streets of this picturesque waterfront town. ...
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    Wednesday - Jul 15, 2026
    Day
    12
    Paducah, United States
    • Paducah, United States
    Just upriver of your ship's dock, the beautiful Tennessee River empties into the Ohio River. Also nearby are confluences with the Cumberland River and the Mississippi. The convergence of these four major rivers crossroads makes Paducah an important port centralized at the axis. Wander along the landing to admire more than 50 murals which highlight the region's rich history. Learn the importance of the town as headquarters for Civil War General Ulysses S. Grant as he embarked to secure Union control of the rivers. Only a block away, the excellent River Discovery Center illuminates for you the importance of the rivers to this historic port. View a treasure trove of incredible works of art created with fabric, needle, and thread at the National Quilt Museum. ...
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    Thursday - Jul 16, 2026
    Day
    13
    • River Cruising
    Cruise from the Ohio River to the Mississippi River on your way to Cape Girardeau. Enjoy onboard activities such as trivia in the lounge or shuffleboard on the top deck. Or, simply relax on your private balcony and delight in the bucolic countryside and rolling river views.
    Friday - Jul 17, 2026
    Day
    14
    • Cape Girardeau, United States
    Perched on the western bank of the Mississippi River, Cape Girardeau is a town reminiscent of the days of pioneers, steamboats, and trading posts. You will feel as if you have stepped back in time, in this enchanting place which has been visited by the likes of Mark Twain, Lewis and Clark, and Ulysses S. Grant. Explore the impressive murals that decorate the historic downtown and chronicle its past and unique relationship with Ol' Man River. Discover important Civil War sites and view a moving commemoration of the Cherokee's forced migration along the Trail of Tears. Roam the quaint downtown and peruse the antique and specialty shops to find the perfect treasure to remember your visit. ...
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    Saturday - Jul 18, 2026
    Day
    15
    St Louis, United States
    • St Louis, United States
    St. Louis is sure to win you over. Admire the scenic riverfront, highlighted by the majestic Gateway Arch, the tallest man-made monument in the U.S. Enjoy St. Louis' many world-class attractions, including the National Great Rivers Museum, which tells stories of the Mississippi River's rich history, the people that rely on the river, and its many ecosystems. Discover the area's extensive history at the excellent Missouri History Museum in the city's lovely Forest Park, the site of the legendary 1904 World's Fair. Or stand in awe at the Cathedral Basilica with its mosaic tile interior which rivals the cathedrals of Europe. Celebrate the United States western expansion and those who made it possible at the recently renovated Gateway Arch monument and the innovative and interactive underground museum. ...
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    Sunday - Jul 19, 2026
    Day
    16
    St Louis, United States
    • St Louis, United States
    End your journey in this unique city with frontier-town roots and Midwest modesty. On your travels home, reflect upon your many wonderful adventures, or choose to explore more in the Gateway to the West.
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